Evaluating eating behaviours, energy homeostasis and obesity in childhood craniopharyngioma

A feasibility study

Summary

Craniopharyngioma, although a non-malignant brain tumour, causes major health problems because of its location. It is near vision nerves, the pituitary gland controlling many hormones, and brain centres controlling appetite. Treatment involves surgery and radiotherapy, which can cause further damage. Obesity and associated long-term risks are common, although we don't understand why. Through this project, we will investigate obesity in young people with craniopharyngioma. We want to find out if obesity is related to overeating from a lack of feeling full, appetite hormones not functioning or low metabolic rate. First, we will assess whether patients and their families are prepared to take part in research. Second, we will investigate which tests are best to use. We will measure the brain's response to food cues using special MRI scans and appetite hormones levels in the blood, as well as metabolic rate and questionnaires on quality of life and typical eating. Patients will eat lunch, so we can assess food choice and portion size. These measures will be analysed in relation to each patient's craniopharyngioma severity and treatment, number and type of hormone problems and level of obesity. Although craniopharyngiomas are rare (1-2 new childhood patients/per year in the South-west), this project has the potential to identify novel interventions. It will make a real impact to improve quality of life and health in craniopharyngioma patients with unmet complex needs related to obesity. These projects could also help us understand how weight problems could develop after other brain injuries.