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Development of an intervention to reduce distress during and after brachytherapy for locally advanced cervical cancer

Chief Investigator

Institution

Dates

Funding Stream

Amount

Pauline Humphrey University Hospitals Bristol NHS Foundation Trust

Jan-2017 to May-2017

RCF Autumn 2016

£6,747

 

Summary

Brachytherapy, a type of internal radiation therapy, is a treatment offered at the Bristol Cancer Institute. It is given following a course of external radiotherapy and chemotherapy to women with locally advanced cervical cancer. It involves placing a number of applicators inside the cervix and vagina and passing a radioactive source into the applicators to deliver a dose of radiation to kill cancer cells.

Some centres give brachytherapy in 3-4 day case procedures. Others give treatments with 1 or 2 inpatient stays, with applicators remaining in place for up to 48 hours. These regimes are thought to be equally as effective in controlling the cancer, but we do not know what difference this makes to patient experience.

A number of reports have indicated that a significant proportion of women experience high levels of physical and/or psychological distress during and after brachytherapy. The causes of distress appears to be highly complex, with contributing factors such as anxiety, poor pain control, recall of pain, isolation, immobility while applicators are in place and the prolonged invasiveness of the procedure. One study showed that over 4 in 10 patients were suffering from post-traumatic stress symptoms associated with brachytherapy 3 months afterwards. It is therefore important to develop an intervention to reduce distress during and after brachytherapy.

The aim of this study is to develop an intervention to improve patient experiences of this highly effective but potentially distressing treatment. A systematic literature review will inform an application for a larger research project to develop the intervention.

Larger Grant

Preliminary data from this small RCF grant supported a successful application for an NIHR HEE/ NIHR ICA Programme Clinical Doctoral Research Fellowship grant worth £322,731.