Nanomedicine & Nanotoxicology
This was led by Dr Margaret Saunders, Consultant Clinical
Scientist and previous Head of BIRCH. The work involved the study
of environmental toxin exposure and child health, specialising in
both in vitro and ex vivo placental barrier models and the
mechanisms of placental transfer and toxicity of chemicals to which
the mother may be exposed during pregnancy.
Publications:
- Hawkins SJ et al. (2018) Nanoparticle-induced neuronal toxicity
across placental barriers is mediated by autophagy and dependent on
astrocytes. Nature Nanotechnology 13(5): 427-433
- Barbour ME et al. (2016) Chlorhexidine hexametaphosphate as a
wound care material coating: antimicrobial efficacy, toxicity and
effect on healing. Nanomedicine (Lond.) (2016) 11(16),
2049-2057
- Cowie H et al. (2015) Suitability of human and mammalian cells
of different origin for the assessment of genotoxicity of metal and
polymeric engineered nanoparticles. Nanotoxicol. 9: Suppl 1,
57-65.
- Dusinska M et al. (2015) Towards an alternative testing
strategy for nanomaterials used in nanomedicine: lessons from
NanoTEST. Nanotoxicol. 9: Suppl 1, 118-32.
- Correia Carreira S, Walker L, Paul KB, and Saunders M (2015) In
vitro models of the human placental barrier - In regione caecorum
rex est luscus. Nanotoxicol. 9: Suppl 1, 135-6
- Correia Carreira S, Walker L, Paul K, and Saunders M
(2015). The toxicity, transport and uptake of nanoparticles
in the in vitro BeWo b30 placental cell barrier model used within
NanoTEST. Nanotoxicol. 9, Suppl 1: 66-78
- Rina Guadagnini et al. (2015) Toxicity screenings of
nanomaterials: challenges due to interference with assay processes
and components of classic in vitro tests. Nanotoxicol.
9, Suppl. 1: 13-24
- Bhabra G et al. (2009) Nanoparticles can cause DNA damage
across a cellular barrier. Nature Nanotechnology 4(12):
876-883
- Saunders M (2009) Advanced review: Transplacental transport of
nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 1(6):
671-684
