Web links to any published articles: |
. |
Manuscripts and textbook chapters (Excluding abstracts) since
2005
2005
- Davey Smith G, Ben-Shlomo Y, Bedwick A, Yarnell J,Lightman
SLand Elwood P. Cortisol, testosterone and coronary heart
disease: prospective evidence from the Caerphilly study.
Circulation 112, 332-340.
- Seale JV, Wood SA, Atkinson HC, Harbuz MS andLightman SL.
Postnatal masculinisation alters the HPA axis phenotype in
the adult female rat. Journal of Physiology 563 (pt.1)
265-274.
- Johnson PL, Hollis JH, Moratalla R,Lightman SL, Lowry CA.
Acute hypercarbic gas exposure reveals functionally distinct
subpopulations of serotonergic neurons in rats. Journal of
Psychopharmacology 19(4), 327-341.
- Henry BA,Lightman SLand Lowry CA. Distribution of
corticotropin-releasing factor binding protein-immunoreactivity in
the rat hypothalamus: association with corticotropin-releasing
factor-, urocortin 1- and vimentin-immunoreactive fibres. Journal
of Neuroendocrinology 17, 135-144.
- Li XF, Bowe JE,Lightman SLand O'Byrne KT. Role of
corticotropin-releasing factor receptor-2 in stress induced
suppression of pulsatile luteinizing hormone secretion in the rat.
Endocrinology 146 (1) 318-322.
- Kaye J, Corrall RJ andLightman SL. A new test for
autonomic and neuroendocrine responses in Diabetes mellitus:
evidence for early vagal dysfunction. Diabetologia 48 (1)
180-186.
- Hollis JH, Lowry CA,Lightman SL. Lipopolysaccharide has
selective actions on sub-populations of catecholaminergic neurons
involved in activation of the hypothalamic-pituitary-adrenal axis
and inhibition of prolactin secretion. Journal of Endocrinology
184, 393-406.
- Johnson PL, Moratalla,Lightman SLand Lowry CA. Are
tuberomammillary histaminergic neurons involved in CO2-mediated
arousal? Experimental Neurology 193, 228-233.
- Seale JV, Wood SA, Atkinson HC,Lightman SLand Harbuz MS.
Organisational role for testosterone and estrogen on adult HPA axis
activity in the male rat. Endocrinology 146(4), 1973-1982.
- Kinsey-Jones JS, XF Li, Bowe JE, Brain SD,Lightman SLand
O'Byrne KT. Effect of calcitonin gene-related peptide on
gonadotrophin-releasing hormone mRNA expression in GT1-7 cells
Journal of Neuroendocrinology, 17, 541-544.
- Crown A,Lightman S. Why is the management of
glucocorticoid deficiency still controversial: a review of the
literature. Clinical Endocrinology 63, 483-492.
- Gardner KL, Thrivikraman KV,Lightman SL,Plotsky PM and Lowry
CA. Early life experience alters behavior during social
defeat: focus on serotonergic systems. Neuroscience 136,
181-191.
2006
- Windle RJ, Gamble LE, Kershaw YM, Wood SA,Lightman SLand
Ingram CD. Gonadal steroid modulation of stress-induced
hypothalamo-pituitary-adrenal activity and anxiety behavior: role
of central oxytocin. Endocrinology 147(5), 2423-2431.
- Spiga F,Lightman SL, Shekhar A and Lowry CA. Injections
of urocortin 1 into the basolateral amygdala induce anxiety-like
behavior and c-Fos expression in brainstem serotonergic neurons.
Neuroscience 138 (4), 1265-1274.
- Kaye JM, Young TM, Mathias CJ, Watson L, Lightman SL.
Neuroendocrine and behavioural responses to CO2
inhalation in central versus peripheral autonomic failure. Clinical
Autonomic Research 16 (2), 121-129.
- Uney JB,Lightman SLMicroRNAs and osmotic regulation.
Proceedings of the National Academy of Science 103, No. 42,
15278-15289.
- Lightman SL. Patterns of exposure to glucocorticoid
receptor ligand. Biochemical Society Transactions 34,
1117-1118.
- Li XF, Bowe JE, Kinsey-Jones JS, Brain SD,Lightman SL,
andO'Byrne KT. Differential role of corticotrophin-releasing
factor receptor types 1 and 2 in stress-induced suppression of
pulsatile luteinising hormone secretion in the female rat. Journal
of Neuroendocrinology 18, 602-610.
- Herbert J, Goodyer IM, Grossman A, Hastings MH, de Kloet
ER,Lightman SL, Lupien SJ, Roozendaal B and Seckl JR. Do
corticosteroids damage the brain? Journal of Neuroendocrinology 18,
393-411.
- Wetherell MA, Crown AL,Lightman SL,Miles JNV, Kaye J and
Vedhara K. The four-dimensional stress test:: psychological,
sympathetic-adrenal-medullary, parasympathetic and
hypothalamic-pituitary-adrenal responses following inhalation of
35% CO2 Psychoneuroendocrinology 31, 736-747.
- Atkinson HC, Wood SA, Kershaw YM, Bate E andLightman SL.
Diurnal variation in the responsiveness of the
hypothalamic-pituitary-adrenal axis of the male rat. Journal of
Neuroendocrinology 18, 526-533.
- Kaye JM and Lightman SL. Corticosteroids and the
cardiovascular response to stress: A pilot study of the 35%
CO2 challenge in Addison's disease. Clinical
Endocrinology 65, 282-286.
- Hollis JH, Evans AK, Bruce KPE,Lightman SL, Lowry CA.
Lipopolysaccharide has indomethacin-sensitive actions on Fos
expression in topographically organized subpopulations of
serotonergic neurones. Brain Behavior and Immunity 20,
569-577.
- Ruddick JP, Evans AK, Nutt DJ,Lightman SL, Rook GAW, Lowry
CA. Tryptophan metabolism in the central nervous system:
medical implications Expert. Reviews in Molecular Medicine Vol. 8,
Issue 20 August 2006.
- Crown A,Lightman S. Management of patients with
glucocorticoid deficiency. Nature Clinical Practice Vol 1 No. 2
62-63.
2007
- 26.
Conway-Campbell BL, McKenna MA, Wiles CC, Atkinson HC, de Kloet
R,Lightman SL. Proteasome-dependent down-regulation of
activated nuclear hippocampal glucocorticoid receptors determines
dynamic responses to corticosterone. Endocrinology; 148 (11):
5470-5477.
- Tran N, Koch A, Berkels R, Boehm O, Zacharowski PA,
Baumgarten G, Knuefermann P, Schott M, Kanczkowski W, Bornstein SR,
Lightman SL, Zacharowski K. Toll-like receptor 9
expression in murine and human adrenal glands and possible
implications during inflammation. Journal of Clinical Endocrinology
& Metabolism 92(7):2773-83.
- Lowry CA, Hollis JH, De Vries A, Pan B, Brunet LR, Hunt JRF,
Paton JFR, Van Kampen E, Knight DM, Evans AK, Rook GAW,Lightman
SL. Identification of an immune-responsive mesolimbocortical
serotonergic system: potential role in regulation of emotional
behavior. Neuroscience 146(2):756-772.
-
Yau JL,
Noble J,
Thomas S,
Kerwin R,
Morgan PE,
Lightman S,
Seckl JR,
Pariante CM. The antidepressant desipramine requires the
ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid
receptor in mice. Neuropsychopharmacology;
32(12):2520-9.
- 30. Ayres
BE, Thomas F, Zacharowski K, Lightman SL, Persad RA.
The stress response in laparoscopic urological surgery. BJU
International 99(6), 1331-1332.
- 31.
Vedhara K, Miles J, Crown A, McCarthy A, Shanks N, Davies
D, Lightman SL, Davey-Smith G, Ben‑Shlomo Y.
Relationship of early childhood illness with adult cortisol in the
Barry Caerphilly Grown (BDG) cohort. Psychoneuroendocrinology
32; 865-873.
- Connan F,Lightman SL, Landau S, Wheeler M, Treasure J, Campbell
IC. An investigation of hypothalamic-pituitary-adrenal axis
hyperactivity in anorexia nervosa: The role of CRH and AVP. Journal
of Psychiatric Research 41, 131-143.
- Orlovsky MA, Spiga F, Lebed YV, Skibo GG,Lightman SL.
Early molecular events in the hippocampus of rats with
streptozotocin-induced diabetes. Neurophysiology; 39 (6):
435-438.
- Juruena MF, Cleare AJ, Papadopoulos AS, Poon L,Lightman SL,
Pariante CM. Different responses to dexamethasone and
prednisolone in the same depressed patients.
Psychopharmacology 189: 225-235.
2008
- John S, Sabo P, Johnson TA, Sung M-H, Biddie SC,Lightman S,
Voss TC, Davis SR, Meltzer PS, Stamatoyannopoulos JA, Hager
GL. Interaction of the glucocorticoid receptor with the
chromatin landscape. Molecular Cell; 29: 611-624.
- McCutcheon JE, Fisher AS,Guzdar E, Wood SA,Lightman SL, Hunt
SP. Genetic background influences the behavioural and molecular
consequences of neurokinin-1 receptor knockout. European
Journal of Neuroscience; 27: 683-690.
- Lightman SL, Wiles CC, Atkinson HC, Henley DE, Russell, GM,
Leendertz JA, McKenna MA, Spiga F, Wood SA, and Conway-Campbell
BL. The significance of glucocorticoid pulsatility.
European Journal of Pharmacology; 583: 255-262.
- Droste SK, de Groote L, Atkinson HC,Lightman SL, Reul JMHM,
Linthorst ACE. Corticosterone levels in the brain show a
distinct ultradian rhythm but a delayed response to forced swim
stress. Endocrinology;149(7):3244-3253.
- Atkinson HC, Wood SA, Castrique ES, Kershaw YM, Wiles CC
andLightman SL. Corticosteroids mediate fast feedback of
the rat hypothalamic-pituitary-adrenal axis via the
mineralocorticoid receptor. American Journal of Physiology;
294 (6): E1011-E1022.
- Spiga F, Harrison LR, Wood SA, Atkinson HC, MacSweeney CP,
Thomson F, Craighead M, Grassie M,Lightman SL. Effect of the
glucocorticoid receptor antagonist Org 34850 on fast and delayed
feedback of corticosterone release. Journal of Endocrinology;
196: 323-330.
- Lightman SL. The neuroendocrinology of stress: A never
ending story. Journal of Neuroendocrinology; 20:
880-884.
- Rockliff H, Gilbert P, McEwan K,Lightman S, Glover D. A
pilot exploration of heart rate variability and salivary cortisol
responses to compassion-focused imagery. Clinical Neuropsychiatry,
5,3: 132-139.
- Pariante CM andLightman SL. The HPA axis in major
depression: classical theories and new developments. Trends
in Neuroscience; 31 (9): 464-468.
- Chen J, Young S, Subburaju S, Sheppard J, Kiss A, Atkinson H,
Wood S,Lightman S, Seeradeil-Le Gal C, Aguilera G.
Vasopressin does not mediate hypersensitivity of the hypothalamic
pituitary adrenal axis during chronic stress. Stress,
Neurotransmitters and Hormones: Annals of the New York Academy of
Sciences; 1148: 349-359.
- Bowe JE, Li XF, Kinsey-Jones JS, Brain SD,Lightman SL, O'Bryne
KT. The role of corticotrophin-releasing hormone receptors in
the calcitoinin gene-related peptide-induced suppression of
pulsatile luteinising hormone secretion in the female rat.
Stress; 11(4): 312-319.
- Kinsey-Jones JS, Li XF, Knox AMI, Wilkinson ES, Zhu XL,
Chaudhary AA, Milligan SR,Lightman SL, O'Byrne KT. Down
regulation of hypothalamic Kisspeptin and its receptor, Kiss1r,
mRNA expression is associated with stress-induced suppression of
luteinizing hormone secretion in the female rat. Journal of
Neuroendocrinology; 21: 20-29.
2009
- Stavreva DA, Wiench M, John S, Conway-Campbell BL, McKenna MA,
Pooley JR, Johnson TA, Voss TC,Lightman SL, Hager GL.
Ultradian hormone stimulation induces glucocorticoid
receptor-mediated pulses of gene transcription. Nature Cell
Biology; 11: 1093-1102.
- Evuarherhe O, Leggett JD, Waite EJ, Kershaw YM, Atkinson
HC,Lightman SL. Organizational role for pubertal
androgens on adult hypothalamic-pituitary-adrenal sensitivity to
testosterone in the male rat. The Journal of Physiology; 587:
2977-2985.
- Henley DE, Russell GM, Douthwaite J, WoodSA, Buchanan F,
GibsonR, WoltersdorfWW, Catterall JR,Lightman SL.
Hypothalamic-pituitary-adrenal axis activation in obstructive sleep
apnea: The effect of continuous positive airway pressure
therapy. Journal of Clinical Endocrinology and Metabolism;
94(11): 4234-4242.
- Gardner KL, Hale MW, Oldfield S,Lightman SL, Plotsky P, Lowry
CA. Adverse experience during early life and adulthood
interact to elevatetpn2mRNA expression in serotonergic neurons
within the dorsal raphe nucleus. Neuroscience; 163:
991-1001.
- Rivers C, Flynn A, Qian X, Matthews L,Lightman S, Ray D, Norman
M. Characterisation of conserved tandem donor sites and
intronic motifs required for alternative splicing in corticosteroid
receptor genes. Endocrinology; 150(11):4958-67.
- Droste SK, Collins A,Lightman SL, Linthorst ACE, Reul
JMHM. Distinct, time-dependent effects of voluntary exercise
on circadian and ultradian rhythms and stress responses of free
corticosterone in the rat hippocampus. Endocrinology; 150(9):
4170-9.
- Li XF, Kinsey-Jones J, Chen YS, Knox A, Lin Y, Petrou N,
Roseweir A,Lightman S, Milligan S, Millar R, O'Byrne K.
Kisspeptin signalling in the hypothalamic arcuate nucleus regulates
GnRH pulse generator frequency. PLoS One; 4: e8334.
- Juruena MF, Pariante CM, Papadopoulos AS, Poon L,Lightman S,
Cleare AJ. Prednisolone suppression test in depression:
prospective study of the role of HPA axis dysfunction in treatment
resistance. British Journal of Psychiatry; 194: 342-349.
- Conway-Campbell BL, Wiles CC,Lightman SL. The
significance of dysregulated basal glucocorticoid pulsatility in
affective disorders. In: Understanding Depression.
Chapter 7. Edited by Carmine M Pariante.
Oxford University Press. Pages 77-90.
- Lowry C, Hale MW, Plant A, Windle RJ, Shanks N, Wood S, Ingram
CD, Renner KJ,Lightman S, Summers CH. Fluoxetine
inhibits corticotrophin-releasing factor (CRF)-induced behavioural
responses in rats. Stress; 12 (3): 225-239.
- Knox AMI, Li XF, Kinsey-Jones JS, Wilkinson ES, Wu XQ, Cheng
YS, Milligan SR,Lightman SL, O'Byrne KT. Neonatal
lipopolysaccharide exposure delays puberty and alters
hypothalamicKiss1andKiss1rmRNA expression in the female rat.
Journal of Neuroendocrinology; 21: 683-689.
- Waite E, Kershaw Y, Spiga F,Lightman S. A glucocorticoid
sensitive biphasic rhythm of testosterone secretion. Journal
of Neuroendocrinology; 21: 737-741.
- Lowry, CA,Lightman SLand Nutt DJ. That warm fuzzy
feeling: brain serotonergic neurons and the regulation of emotion.
Journal of Psychopharmacology; 23(4):392-400.
- Spiga F andLightman SL. Dose-dependent effects of
corticosterone on nuclear glucocorticoid receptors and their
binding to DNA in the brain and pituitary of the rat. Brain
Research; 1293:101-7.
- Henley DE, Buchanan F, Gibson R, Douthwaite JA, Wood SA,
Woltersdorf WW, Catterall JR,Light man SL. Plasma apelin
levels in obstructive sleep apnea and the effect of continuous
positive airway pressure therapy. Journal of Endocrinology;
203: 181-188.
- Li XF. Kinsey-Jones JS, Bowe JE, Wilkinson ES, Brain
SD,Lightman SL, O'Byrne KT. A role for the medial preoptic
area in CGRP-induced suppression of pulsatile LH secretion in the
female rat. Stress;12(3): 259-267.
- Shufflebotham J, Wetherell MA, Hince D, Hood S,Lightman S, Nutt
D, Probert C, Potokar J. Females with diarrhoea-predominant
irritable bowel syndrome show an increased pressure response to 35%
carbon dioxide stress challenge. Stress. 12 (1): 30-36.
- Droste SK, de Groote L,Lightman SL, Reul JMHM, Linthorst
ACE. The ultradian and circadian rhythms of free
corticosterone in the brain are not affected by gender: An in vivo
microdialysis study in Wistar rats. Journal of
Neuroendocrinology, 21: 132-140.
- Henley D, Leendertz J, Russell G, Wood S, Taheri S, Woltersdorf
W,Lightman SL. Development of an automated blood sampling
system for use in humans. Journal of Medical Engineering and
Technology; 33(3): 199-208.
- Evuarherhe O, Wood S, Atkinson H,Lightman S. Reversal of
hypothalamo-pituitary-adrenal response to oestrogens around
puberty. Journal of Endocrinology; 202(2): 279-285.
- Gardner KL, Hale MW,Lightman SL, Plotsky P, Lowry CA.
Adverse early life experience and social stress during adulthood
interact to increase serotonin transporter mRNA expression.
Brain Research; 1305: 47-63.
- Pearson RM,Lightman SL, Evans J. Emotional sensitivity
for motherhood: Late pregnancy is associated with enhanced accuracy
to encode emotional faces. Hormones and Behavior;
56(5):557-63.
- Spiga F, Harrison. LR, Wood S, Knight DM,MacSweeney
CP, Thomson F, Craighead M, Lightman SL. Blockade of the
V1b receptor reduces ACTH, but not corticosterone,
secretion induced by stress without affecting basal HPA axis
activity. Journal of Endocrinology; 200(3): 273-283.
- Spiga F, Harrison LR, MacSweeney CP, Thomson FJ,
CraigheadM,Lightman SL. Effect of vasopressin 1b receptor
blockade on the hypothalamic-pituitary-adrenal response of
chronically stressed rats to a heterotypic stressor. Journal
of Endocrinology; 200(3): 285-291.
- Pearson RM, Cooper RM, I. Penton-Voak S,Lightman SL, Evans
J. Depressive symptoms in early pregnancy disrupt attentional
processing of infant emotion. Psychological Medicine; 12:
1-11.
2010
- Walker JJ, Terry JR, Lightman SL. Origin of ultradian
pulsatility in the hypothalamic-pituitary-adrenal axis. Proceedings
of the Royal Society B: Biological Sciences;
277(1688):1627-33.
- Russell G, Henley D, Leendertz J, Douthwaite J, Wood S, Stevens
A, Woltersdorf W, Peeters B, Ruigt G, White A, Veldhuis J,Lightman
S. Rapid glucocorticoid receptor mediated inhibition of
hypothalamic-pituitary-adrenal ultradian activity in healthy
males. Journal of Neuroscience; 30: 6106-6115.
- Cameron A, Henley D, Carrell R, Zhou A, Clarke A,Lightman
SL. Temperature-responsive release of cortisol from its
binding globulin: A protein thermocouple. Journal of Clinical
Endocrinology & Metabolism; 95(10):4689-95.
- Atkinson HC, Leggett JD, Wood SA, Castrique ES, Kershaw
YM,Lightman SL. Regulation of the
hypothalamic-pituitary-adrenal axis circadian rhythm by
endocannabinoids is sexually diergic. Endocrinology; 151(8):
3720-3727.
- Sarabdjitsingh R, Conway-Campbell B, Leggett J, Waite E, Meijer
O, de Kloet R,Lightman SL. Stress responsiveness
varies over the ultradian glucocorticoid cycle in a brain-region
specific manner. Endocrinology; 151(11):5369-79.
- Lightman SLand Conway-Campbell BL. The crucial role of
pulsatile activity of the HPA axis for continuous dynamic
equilibration. Nature Reviews Neuroscience; 11(10):
710-8.
- PerogamvrosI, Underhill C, HenleyDE, Hadfield KD, NewmanWG,
Ray DW, LightmanSL, Hammond GL &
TrainerPJ. A novel inherited corticosteroid-binding globulin
(CBG) variant causes functional CBG deficiency and a very low total
serum cortisol concentration with normal bioavailable cortisol
levels. Journal of Clinical Endocrinology & Metabolism;
Vol. 95, No. 10 E142-E150.
- 79.
Conway-Campbell BL, Sarabdjitsingh RA, McKenna MA, Pooley
JR, Kershaw YM, Meijer OC, de Kloet ER, Lightman SL.
Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing
of the Clock gene Period 1 in rat hippocampus. Journal of
Neuroendocrinology; 22: 1093-1100.
- Windle R, Wood SA, Kershaw YM, Lightman SL, Ingram
CD. Reduced stress responsiveness in pregnancy: Relationship
with pattern of forebrain c-fos mRNA expression. Brain
Research Brain; 1358:102-9.
- Walker JJ, Terry JR, Tsaneva-Atanasova K, Armstrong SP, McArdle
CA,Lightman SL. Encoding and decoding mechanisms of pulsatile
hormone section. Journal of Neuroendocrinology;
22(12):1226-1238.
- Li XF, Lin YS, Kinsey-Jones JS, Milligan SR,Lightman SL,
O'Byrne KT. The role of the bed nucleus of the stria
terminalis in stress-induced inhibition of pulsatile LH secretion
in the female rat. Journal of Neuroendocrinology; 23; 3-11.
- Biddie SC andLightman SL. Epigenetics: A lasting
impression? Neuroendocrinology Briefings 36. Journal of
Neuroendocrinolology; 23(2): 194-195.
- Sarabdjitsingh R, Spiga F, Oitzl M, Kershaw Y, Meijer
O,Lightman SL,de Kloet R. Recovery from disrupted
ultradian glucocorticoid rhythmicity reveals a dissociation between
hormonal and behavioral stress responsiveness. Journal of
Neuroendocrinology; 22: 862-871.
- Vedhara K, Brant H, Alexiou A, Petrie KJ, Miles JNV, Lightman
SL. An investigation into the effects of social evaluation on
cardiovascular and endocrine responses to the CO2 stress
test in humans. Stress; 13(3):195-202.
- Juruena M, Cleare A, Papadopoulos A, Poon L,Lightman SL,
Pariante C. The prednisolone test in depression:
Dose-response and changes with anti-depressant treatment.
Psychoneuroendocrinology; 35: 1486-1491.
-
Brant H,
Wetherell MA,
Lightman S,
Crown A,
Vedhara K. An exploration into physiological and
self-report measures of stress in pre-registration doctors at the
beginning and end of a clinical rotation. Stress; 13:
155-162.
-
Kinsey-Jones JS,
Li XF,
Knox AM,
Lin YS,
Milligan SR,
Lightman SL,
O'Byrne KT. Corticotrophin-releasing factor alters the
timing of puberty in the female rat. Journal of
Neuroendocrinology; 22(2):102-9.
2011
- Conway-Campbell BL, George CL, Pooley JR, Knight DM, Norman MR,
Hager GL,Lightman SL. The HSP90 molecular chaperone cycle
regulates cyclical transcriptional dynamics of the glucocorticoid
receptor and its co-regulatory molecules CBP/P300 during ultradian
ligand treatment. Molecular Endocrinology; 25(6):944-54.
- Biddie SC, John S, Sabo PJ, Thurman RE, Schiltz RL, Johnson TA,
Sung MH, Trump S,Lightman SL, Vinson C, Stamatoyannopoulos JA and
Hager GL. Transcription Factor AP1 Potentiates Chromatin
Accessibility and Glucocorticoid Receptor Binding. Mol Cell;
43(1):145-55.
- Andrews MH, Wood SA, Windle RJ,Lightman SL, Ingram CD.
Acute glucocorticoid administration rapidly suppresses basal and
stress-induced hypothalamo-pituitary-adrenal axis activity.
Endocrinology 153(1):200-11.
- Lin Y, Xiao Li XF, Lupi M, Kinsey-Jones JS, Be S, Lightman SL,
and Kevin T O'Byrne KT. The role of the medial and central
amygdala in stress-induced suppression of pulsatile luteinizing
hormone secretion in female rats. Endocrinology;
152(2):545-55.
- Wu XQ, Li XF, Ye B, Popat N, Milligan SR,Lightman SL, O'Byrne
KT. Neonatal programming by immunological challenge: effects
on ovarian function in the adult rat. Reproduction ;
141(2):241-8.
- Johnson PL, Fitz SD, Hollis JH, Moratalla R,Lightman SL,
Shekhar A, Lowry CA. Induction of C-fos in
"panic/defence"-related brain circuits following brief hypercarbic
gas exposure. Journal of Psychopharmacology;
25(1):26-36.
- O'Keane V,
Lightman S,
Marsh M,
Pawlby S,
Papadopoulos AS,
Taylor A,
Moore R,
Patrick K. Increased pituitary-adrenal activation and
shortened gestation in a sample of depressed pregnant women: a
pilot study. Journal of Affective Disorders; 130:300-305.
- Pearson RM,Lightman SLand Evans J. Attentional processing
of infant emotion during late pregnancy and mother-infant relations
after birth. Archives of Women's Mental Health; 14(1):23-31.
- Spiga F, Waite EJ, Liu Y, Kershaw YM, Aguilera G,Lightman
SL. ACTH-dependent ultradian rhythm of corticosterone
secertion. Endocrinology; 152(4):1448-57.
- Henley DE &Lightman SL. New insights into
corticosteroid-binding globulin and glucocorticoid delivery.
Neuroscience; 180:1-8.
- Biddie SC &Lightman SL. Epigenetics: A lasting
impression? Journal of Neuroendocrinology; 23: 194-195.
- Mason BL, Thomas SA, Lightman SL, Pariante
CM. Desipramine
treatment has minimal effects on the brain accumulation of
glucocorticoids in P-gp-deficient and wild-type mice.
Psychoneuroendocrinology; 36(9):1351-60.
- Biddie SC, Conway-Campbell BL,Lightman SL. Dynamic
regulation of glucocorticoid signalling in health and
disease. Rheumatology; 51:403-412.
- Spiga F, Liu Y, Aguilera G,Lightman SL. Temporal Effect
of Adrenocorticotrophic Hormone on Adrenal Glucocorticoid
Steroidogenesis: Involvement of the Transducer of Regulated Cyclic
AMP-Response Element-Binding Protein Activity. Journal of
Neuroendocrinology; 23(2):136-42.
- Pearson RM,Lightman SL, Evans J. The impact of breast
feeding on mothers' attentional sensitivity towards infant
distress. Infant Behavior and Development; 34(1): 200-5.
-
Spiga F,
Knight DM,
Droste SK,
Conway-Campbell B,
Kershaw Y,
MacSweeney CP,
Thomson FJ,
Craighead M,
Peeters BW,
Lightman SL. Differential effect of glucocorticoid
receptor antagonists on glucocorticoid receptor nuclear
translocation and DNA binding. J
Psychopharmacol ; 25(2):211-21.
- Henley DE, Kaye JM,Lightman SL. The Endocrine Response to
Stress. Chapter in: Pituitary and Hypothalamic Diseases -
Neuropsychiatric endocrinological disorders. Edited by Wass
JAH and Stewart PM. Oxford Textbook of Endocrinology and
Diabetes, 2.6.3; pages 287-294.
- O'Keane V,Lightman S, Patrick K, Marsh M, Papadopoulos AS,
Pawlby S, Seneviratne G, Taylor A, Moore R. Changes in the
maternal hypothalamic-pituitary-adrenal axis during the early
puerperium may be related to postpartum 'blues'. Journal of
Neuroendocrinology; 23: 1149-1155.
- Gardner MP, Lightman S, Gallacher J, Hardy R, Kuh D,
Ebrahim S, Bayer T, Ben-Shlomo Y and the Halcyon study
team. Diurnal cortisol
patterns are associated with physical performance in the Caerphilly
Prospective Study (CaPS). International Journal of
Epidemiology;40(6):1693-1702.
- George CL,Lightman SL, Biddie SC. Transcription factor
interactions in genomic nuclear receptor function.
Epigenomics; 3: 471-485.
2012
- Walker JJ, Spiga F, Waite E, Kershaw Y, Terry JR,Lightman
SL. The origin of glucocorticoid hormone oscillations.
PLoS Biology; 10(6): e1001341.
doi:10.1371/journal.pbio.1001341.
- Rankin J, Walker JJ, Windle R, Lightman SL, Terry JR.
Characterizing dynamic interactions between ultradian
glucocorticoid rhythmicity and acute stress using the phase
response curve. PLoS One. 2012;7(2):e30978. Epub 2012 Feb
21.
- Kinsey-Jones JS, Grachev P, Li XF, Lin YS, Milligan SR,Lightman
SL, O'Byrne KT. The inhibitory effects of neurokinin B on
GnRH pulse generator frequency in the female rat.
Endocrinology; 153(1):307-15.
- Waite EJ, McKenna M, Kershaw Y, Walker JJ, Cho K, Piggins
HD,Lightman SL. Ultradian corticosterone secretion is
maintained in the absence of circadian cues. European Journal
of Neuroscience - article first published online: 23 July 2012 -
DOI: 10.1111/j.1460-9568.2012.08213.x.
- Grachev P, Li X-F, Kinsey-Jones JS, di Domenico AL, Millar
RP,Lightman SL, O'Byrne KT. Suppression of the GnRH
pulse generator by neurokinin B involves a kappa-opioid
receptor-dependent mechanism. Endocrinology;
153(10):4894-904. Epub 2012 Aug 17.
- Qian XX, Droste S,Lightman S, Reul H, Linthorst A.
Circadian and ultradian rhythms of free glucocorticoid hormone are
highly synchronized between the blood, the subcutaneous tissue and
the brain. Endocrinology; 153(9):4346-4353.
- Conway-Campbell BL, Pooley JR, Hager GL,Lightman SL.
Molecular dynamics of ultradian glucocorticoid receptor
action. Molecular and Cellular Endocrinology;
348:383-393.
- Johnson PL, Samuels BC, Fitz SD, Lightman SL, Lowry CA, Shekhar
A. Activation of the orexin 1 receptor is a critical
component of CO2 mediated anxiety and hypertension but
not bradycardia. Neuropsychopharmacology; 37(8):1911-22.
- Hazell GGJ, Hindmarch
CC, Pope GR, Roper JA, Lightman SL, Murphy D, O'Carroll AM, Lolait
SJ.
Gprotein-coupled receptors in the
hypothalamic paraventricular and supraoptic nuclei - serpentine
gateways to neuroendocrine homeostasis. Frontiers in
Neuroendocrinology; 33:45-66.
- Galhardo J, Hunt LP,Lightman SL, Sabin MA, Bergh C, Sodersten
P, Shield JPH. Normalizing eating behaviour reduces body
weight and improves gastro-intestinal hormonal secretion in obese
adolescents. Journal of Clinical Endocrinology and Metabolism;
97:E193-E201.
- Lin YS, Li XF, Shao B, Hu MH, Goundry A, Jeyaram A,Lightman SL,
O'Byrne KT. The role of GABAergic signalling in
stress-induced suppression of gonadtrophin-releasing hormone pulse
generator frequency in female rats. Journal of
Neuroendocrinology; 24:477-488.
- Vedhara K, Metcalfe C, Brant H, Crown A, Northstone K,Dawe
K,Lightman S, Davey Smith G. Maternal mood and
neuroendocrine programming: effects of time of exposure and sex
Journal of Neuroendocrinology; 24:999-1011.
- Dawson C, Dhanda A, Conway-Campbell B, Di Mambro A,Lightman S,
Dayan C. NFκB and glucocorticoid receptor activity in steroid
resistance. Journal of Receptors and Signal Transduction;
32(1):29-35.
- Grachev P, Xiao Li X-F; Lin YS, Hu MH, Elsamani L; Paterson SJ,
Millar RP,Lightman SL; O'Byrne KT. GPR54-dependent
stimulation of luteinizing hormone secretion by neurokinin B in
peripubertal rats: PLoS One 2012;7(9):e44344. doi:
10.1371/journal.pone.0044344. Epub 2012 Sep 28.
- Pearson R,Lightman SL, Evans J. Symptoms of depression
during pregnancy are associated with increased systolic blood
pressure responses towards infant distress. Archives Women's
Mental Health; 15(2):95-105.
- Turner-Cobb J, Jessop D andLightman SL. Effects of
childhood stress: Hardwired or reversible? The Biologist;
59(4):31-35.
|
|